One Dintwe, PhD (Clinical Science and Immunology)
One joined CHIL in January 2015. She completed her PhD in June 2014 at the University of Cape Town (UCT) in Clinical Sciences and Immunology under supervision and mentorship of Professors Tom Scriba and Willem Hanekom at the South African TB Vaccine Initiative (SATVI). Her work provided novel immunological tools to characterise the memory phenotype and function of antigen-specific CD4+ T cells after vaccination and in infection.
This work led to the identification of a novel subset of TB-specific memory T cells and the further characterisation of these CD4+ T cells to begin to attempt to deconvolute the role of these cells in TB immunity. One has molecular and flow cytometry assay skills, experience in clinical trials and the application of ISO15189 quality management standards in a research laboratory setting. At CHIL, One has local oversight for quality control of Good Clinical Lab Practice (GCLP)-compliant assays and is studying cellular immune responses to HIV vaccines.